As for the king: in 1765 poor King George III experienced his first attack of porphyries, an inherited disease. He suffered with severe porphyries fever from 1788 on with accompanying bouts of mental illness, went blind, remained in isolation, wearing a straight jacket, and behind bars in his apartments at Windsor Castle, and finally died, having lost the America Revolution.
Queen Anne and other royals suffered from the same inherited disease. Meanwhile, Princess Charlotte and her still lovely daughters continued to draw more and more drawings of new and exciting plants. Can anyone truly think of a greater endeavor for royal young ladies and their mother?